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Beilstein J. Org. Chem. 2017, 13, 239–246, doi:10.3762/bjoc.13.26
Graphical Abstract
Scheme 1: In-flask (batch) preparation of imidazo[1,2-a]pyridin-2-yl-1,2,4-oxadiazoles (S1P1 agonists) [27].
Scheme 2: Gram-scale synthesis of mGlu5 NAM by continuous flow in combination with microfluidic extraction.
Scheme 3: Gram-scale synthesis of imidazo[1,2-a]pyridin-2-yl-1,2,4-oxadiazole S1P1 agonist scaffold by contin...